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COLLAGENASE & NEUTRAL PROTEASE ENZYME

(contract last updated 08/22/2008)
SCOPE: Contract for Collagenase & Neutral Protease Enzymes.  The enzymes will be used in the process of human islet isolation for both research and clinical transplantation programs.

CONTRACT # DESCRIPTION

08-5925

COLLAGENASE & NEUTRAL PROTEASE ENZYME

CONTRACT ORIGIN: ADDITIONAL INFORMATION:
UW-Madison
Purchasing Services
21 N Park St, Ste 6101
Madison, WI 53715-1218
UW-Madison users contact:
Judy Millard
(608) 262-6335 FAX (608) 262-4467
TDD: 608-262-0825
jmillard@bussvc.wisc.edu
 

Non-UW-Madison users contact: Vendor Representative

COOPERATIVE PURCHASING: YES
CONTRACT TERM:

September 1, 2007 through August 31, 2008, with automatic renewal extensions to August 31, 2010, unless amended, cancelled or rebid. The University reserves the right to extend beyond the Contract Term if deemed to be in the best interest of the University.


Manufacturer(s) SERVA NORDMARK
Vendor(s)
036540
Crescent Chemical Company Inc
2 Oval Dr
Islandia  NY  11749
Sales Representative: PHONE # FAX #
Carol Wasserman 631-348-0333 631-348-0913
  PHONE # FAX #
Ordering/Expediting: 631-348-0333 631-348-0913
Invoice Information: 631-348-0333 631-348-0913
Returns: 631-348-0333 631-348-0913
Minority Reporting: 631-3631-348-091348-0333 650-871-7152
E-mail crescent@creschem.com
Website www.crescentchemical.com
Commodity Code

115-10
269-44

Federal Employee ID # (FEIN) 11-1958016
F.O.B.

FOB Germany.  All shipping charges including insurance charges will be added.  These charges cannot be estimated because they depend on the weight of the shipment including dry ice, the value of the shipment and the Euro currency rate.

Terms: N/30
Delivery: 14 days ARO
Invoicing: Invoices shall reflect contract pricing.
Warranty: 2 hours after receipt of shipment
Orders: Phone, Fax
Back Orders:

Will notify ordering department within 48 hours of order/release.

Return Policy:

A “Confirmation of Reception” form will be in an envelop on the outside of the package.  This form must be filled in and one (1) copy faxed to Serva Nordmark at 011494122712286 and one (1) copy faxed to Crescent Chemical at 631-348-0913 within 2 hours after receipt.  To ensure the correct temperature during transportation, a temperature indicator will be included in the shipment.  If the enzymes were exposed to temperatures higher than 37°C , one of the circles will turn red.  Mark the status on the “Confirmation of Reception” form.  If any circle on the indicator form has turned red, do not use the enzymes.  Serva Nordmark will not accept reclamations regarding proper shipment conditions if they do not receive the “Confirmation of Reception” form within 2 hours of receipt of shipment.

Pricing Information:

SEE BELOW

DESCRIPTION
UNIT PRICE PER VIAL
 
COLLAGENASE
$1,497.00
Manufacturer Serva Nordmark
Catalog # 17455
Packaging glass vials
 
NEUTRAL PROTEASE
$462.00
 
Manufacturer Serva Nordmark
Catalog # 30301.12
Packaging glass vials

All other related items may be purchased at 0% discount off current price list dated 2006-2007.

Prices will increase when Euro currency exchange rate goes above 1,6000.  Contact Purchasing Agent.

Specifications

A. Product Specifications
1 Collagenase enzyme purified from Clostridium histolyticum:
  Activity (PZ activity according to Wunsch) ≥ 3.0 U/mg of lyophilisate
  Activity/vial ≥ 2000 U
  Neutral Protease Activity (DMC assay) ≤ 0.05 U/mg of lyophilisate
  Trypsin-like Activity (BAEE assay) ≤ 0.5 U/mg of lyophilisate
  Endotoxin (LAL assay) ≤ 10 EU/mg
2 Neutral protease enzyme purified from Clostridium histolyticum:
  Activity (DMC assay) ≥ 0.1 U/mg of lyophilisate
  Activity/vial ≥ 100 U
B. Product Evaluation Process and Shipping Schedule
1 Contractor must ship 2 evaluation sets (2 vials of Collagenase and 4 vials of Neutral Protease) with 13 sets of the same lot of each product to be held in reserve until the department deems the lot suitable for use. If the evaluation sets are deemed acceptable by the department the remaining reserved 13 sets of enzymes will be shipped within 14 days of notification by the department. (Since material must be shipped on dry ice from Germany, shipments are only dispatched on Monday or Tuesday). If the lot is deemed unacceptable by the department, one additional evaluation set of enzymes consisting of new lots (1 vials of Collagenase NB1 and 2 vials of Neutral Protease) will be shipped to the department at 50% off the usual price, with 13 sets of the same lots of each product held in reserve until the department deems the lots suitable for use. To be realistic, in the near future we will not have several lots, so only one additional lot evaluation is possible at a time. Upon selection of a suitable lot the department will be billed for a total of 15 sets of each product.
2 Contractor agrees to the following shipping schedule for the evaluation sets of enzymes (2 vials of collagenase and 4 vials of Neutral Protease):
   
  October 1, 2007 (must have order by September 1 to meet October 1)
  4-Dec-07
  4-Mar-08

Revision History

AMENDMENT #1 (8/22/08): issued to show price increase effective September 1, 2008 and add information about price increase if euro currency exchange rate goes above 1,6000. 
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